December 13, 2017
CBC is inviting new applications for the Accelerator Award program
Accelerator Award is a milestone-driven award program ($100,000 for 1st year) focused on translational research toward therapeutics or associated biomarkers and diagnostics.
Spring 2018 round Letter of Intent (LOI) submissions open January 8, 2018 and close January 12, 2018.
Applicants, if selected, MUST be available to present their projects at a CBCAN meeting on February 1 and/or February 8, 2018. Both meetings will be held on a Thursday, from 4:00-7:00 PM, at Prentice Women Hospital Conference Center downtown Chicago.
MARK YOUR CALENDARS!
December 13, 2017
CBC Newsletter, vol. 24
CBC invites new applications for the Accelerator and Catalyst Award programs
December 13, 2017
A NU team tracks down a novel protein involved in glioblastoma survival and resistance to current therapies
An important new finding with implications for developing a treatment for glioblastoma has just been published in Cancer Cell by a NU team led by Shi-Yuan Cheng. The group identified a protein kinase MST4-dependant pathway that plays a tumor-promoting role in glioblastoma through increasing autophagic activity. Autophagy is unfortunately frequently induced by anti-cancer treatments. However, the scientists discovered a novel protein called ATG4B—a substrate of MST4—that, when inhibited, led to reductions in tumor size and prolonged survival in mice treated with radiotherapy. A prior CBC awardee, Jack Kessler, NU, was part of the team which made this discovery. Kessler was a co-recipient of a CBC Catalyst Award (2008). He was also a keynote speaker at the 5th Annual CBC Symposium (2007), “Where Science Goes Next: Translation of Basic Discovery for Human Health.” Congratulations to all scientists involved in this project!
Congratulations to Alexander Mankin and his team from UIC, for the new publication in PNAS: “Kinetics of drug–ribosome interactions defines the cidality of macrolide antibiotics.” The study, which compared the binding and dissociation kinetics of bacteriostatic and bactericidal antibiotics to ribosomes suggests that it is the prolonged attachment (or slow dissociation rate) of the antibiotic to a ribosome that infers its -cidal property; likely by a mechanism of time-dependent depletion of factors required for proper translation. The finding opens new possibilities into designing “more sticky” or more slowly dissociating bactericidal antibiotics. Mankin has been affiliated with CBC since 2009 when he received a CBC Spark Award. The same year he was also an invited speaker at the 7th Annual CBC Symposium: “The Biology of Non-Coding RNAs: Old Molecules, New Actions.” In addition, Mankin served on the Spark Review Panel (2010-2011).
December 11, 2017
Understanding skin in health and disease at the center of interest of many CBC awardees at NU
The December 2017 issue of Northwestern Medicine Magazine features an article devoted to skin research conducted at NU. Remarkably, several NU scientists that are highlighted in the story have received CBC support in the past: Kathleen Green, Amy Paller and her postdoc, Duncan Dam, Jaehyuk Choi, Chad Mirkin and Bethany Perez White are included in this august group (for details see the notes below the article). Their research spans areas from studying properties of healthy skin to mechanisms underlying the development of severe skin maladies such as melanoma to developing skin permeable therapeutics using nanotechnology. As Jaehyuk Choi, a CBC Catalyst Award (2017) recipient states in the article, “We pride ourselves as a department that has a robust bedside-to-bench-to-bedside pipeline.” CBC congratulates each and every scientist mentioned in the article for their dedication and contributions to basic and translational science.
October 18, 2017 (Updated: December 8, 2017)
The CBC is proud to announce that over 1900 publications have been attributed to CBC funding! The countdown to reach 2000 is on! The winning publication will be featured on the CBC homepage and the CBC awardee(s) will receive a surprise gift to commemorate the occasion! The current number to reach 2000 is:
April 25-26, 2018
UChicago Computation Institute
GlobusWorld 2018: Connecting your Research Universe
May 10, 2018
NU Cognitive Neurology and Alzheimer’s Disease Center
24th Annual Alzheimer Day
January 30-31, 2018
SBIR/STTR Grant Writing Workshop
PROPEL is hosting this 2-day Intensive Workshop, provided by BBC Entrepreneurial Training & Consulting (BBCetc), that will cover all aspects of writing SBIR/STTR grants focused on life science technologies including: eligibility, sources of funding and agency differences, understanding what reviewers look for, step-by-step instruction on how to write each section of your proposal.
▸ More info and registration details