June 23, 2020 | Jola Glotzer
Cite us — we’ll “cite” you back!
Forty-one new publications attributed to twenty-five CBC Awards contribute to a total of 2566 publications that are the result of CBC-sponsored research to date
The CBC is pleased to share that, since February 2020, forty-one new research articles acknowledging CBC support have been published. These publications are a result of CBC-sponsored research linked to twenty-five CBC Awards: one Accelerator Award, one Director’s Fund Award, eight Catalyst Awards, one Infrastructure, two Lever Awards, three Postdoctoral Research Awards, five Recruitment Resources Fund Awards, two CBC Scholar Awards and two Sparks. To date, 2566 research papers in total have been published as a result of CBC-funding!
Congratulations to all authors involved in the published research!
Congratulations to all CBC awardees and community members who have recently published the results of their CBC-sponsored research:
CBC Accelerator Award (A-007; 2018)
Award Title: Establishing a Novel Therapy for RA Patients
PI: Shiva Shahrara (UIC)
New publications attributed to the award:
- Umar S, Palasiewicz K, Van Raemdonck K, Volin MV, Romay B, Amin MA, Zomorrodi RK, Arami S, Gonzalez M, Rao V, Zanotti B, Fox DA, Sweiss N, Shahrara S. IRAK4 inhibition: a promising strategy for treating RA joint inflammation and bone erosion. Cell Mol Immunol. 2020 May 15. doi: 10.1038/s41423-020-0433-8. Online ahead of print. (PubMed)
- Van Raemdonck K, Umar S, Shahrara S. The pathogenic importance of CCL21 and CCR7 in rheumatoid arthritis. Cytokine Growth Factor Rev. 2020 May 18:S1359-6101(20)30090-3. Online ahead of print. (PubMed)
CBC Director’s Fund Award (DF-003; 2019)
Award Title: Development of Fluorine-labelled IGF-1 Probes for Future Imaging in vivo
PI: Richard Kraig (UChicago)
New publication attributed to the award:
- Won L, Kraig RP. Insulin-like growth factor-1 inhibits spreading depression-induced trigeminal calcitonin gene related peptide, oxidative stress & neuronal activation in rat. Brain Res. 2020 Apr 1;1732:146673. (PubMed)
CBC Catalyst Award (C-040; 2018)
Award Title: An “And-Gate” for Optogenetic Control Of Protein Kinases
PIs: Andrei Karginov (UIC), Michael Glotzer (UChicago)
New publication attributed to the award:
- Collins KB, Kang H, Matsche J, Klomp JE, Rehman J, Malik AB, Karginov AV. Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis. J Cell Biol. 2020 Feb 3;219(2):e201903023. (PubMed)
CBC Catalyst Award (C-048; 2013)
Award Title: Immunotherapy-Mediated Interference of Bacterial Quorum Sensing
PIs: Michael Federle (UIC), Matthew Tirrell (UChicago)
New publication attributed to the award:
- Capodagli GC, Tylor KM, Kaelber JT, Petrou VI, Federle MJ, Neiditch MB. Structural basis of Rgg protein binding to their regulatory pheromones and target DNA promoters. BioRxiv. Preprint posted April 30, 2020. (BioRxiv)
CBC Catalyst Award (C-064; 2016)
Award Title: Toward the Visualization of Spliceosomal Intermediates
PIs: Yuan He (NU), Joseph Piccirilli (UChicago), Jonathan Staley (UChicago)
New publication attributed to the award:
- Abdella R, Aggarwal M, Okura T, Lamb RA, He Y. Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation. PNAS. March 3, 2020 117 (9) 4931-4941. (PubMed)
CBC Catalyst Award (C-084; 2018)
Award Title: In situ Lysosomal Ion Imaging as a Sensitive Diagnostic for Lysosomal Disorders
PIs: Yamuna Krishnan (UChicago), Dimitri Krainc (NU)
New publications attributed to the award:
- Jani MS, Zou J, Veetil AT, Krishnan Y. A DNA-based fluorescent probe maps NOS3 activity with subcellular spatial resolution. Nat Chem Biol. 2020 Jun;16(6):660-666. (PubMed)
- Veetil AT, Zou J, Henderson KW, Jani MS, Shaik SM, Sisodia SS, Hale ME, Krishnan Y. DNA-based fluorescent probes of NOS2 activity in live brains. Proc Natl Acad Sci U S A. 2020 Jun 17:202003034. Online ahead of print. (PubMed)
CBC Catalyst Award (C-085; 2018)
Award Title: Defining Prostate Tumor Malignancy with Activity-Dependent Pet Probes
PIs: Raymond Moellering (UChicago), Sarki Abdulkadir (NU)
New publication attributed to the award:
- Chang JW, Bhuiyan M, Tsai HM, Zhang HJ, Li G, Fathi S, McCutcheon DC, Leoni L, Freifelder R, Chen CT, Moellering RE. In Vivo Imaging of the Tumor-Associated Enzyme NCEH1 with a Covalent PET Probe. Angew Chem Int Ed Engl. 2020 May 16. Online ahead of print. (PubMed)
CBC Catalyst Award (C-086; 2018)
Award Title: Observing Protein Allostery Dynamics by Single-Particle Imaging
PIs: Xiaojing Yang (UIC), Minglei Zhao (UChicago)
New publication attributed to the award:
- Li J, Xie Y, Cornelius S, Jiang X, Kordon SP, Sando R, Pan M, Leon K, Südhof TC, Zhao M, Araç D. Structure of the teneurin-latrophilin complex: Alternative splicing controls synapse specificity by a novel mechanism. BioRxiv. Posted January 14, 2020. (BioRxiv)
CBC Catalyst Award (C-088; 2018)
Award Title: Quantitative Matrisomics: A Novel Approach to Decipher Fibrosis
PIs: Alexandra Naba (UIC), John Varga (NU)
New publication attributed to the award:
- Reis M, Lee F, Bedran-Russo AK, Naba A. Proteomic Profiling of the Human Dentin Identifies Age-Related Differences in the Composition and Solubility of the Matrisome. BioRxiv. Preprint posted May 28, 2020. (BioRxiv)
CBC Catalyst Award (C-089; 2018)
Award Title: Carbapenem-Resistant K. Pneumoniae Genomic Biomarkers that Predict Poor Outcomes
PIs: Alan Hauser (NU), Zackery Bulman (UIC)
New publication attributed to the award:
- Kochan TJ, Ozer EA, Pincus NB, Fitzpatrick MA, Hauser AR. Complete Genome Sequence of Klebsiella pneumoniae Strain TK421, a Conjugative Hypervirulent Isolate. Microbiol Resour Announc. 2020 Jan 16;9(3). (PubMed)
CBC Infrastructure Award (IN-009; 2014)
Award Title: Infrastructure Initiative: Direct Electron for the Biological CryoEM
PIs: Alfonso Mondragon & Jay Walsh (NU)
(A parts of the published work was conducted in the facility funded by the CBC Infrastructure Award to NU)
New publication attributed to the award:
- Bobbala S, Allen SD, Yi S, Vincent M, Frey M, Karabin NB, Scott EA. Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off-on cytotoxicity. Nanoscale. 2020 Mar 5;12(9):5332-5340. (PubMed)
CBC Lever Award (L-006; 2015)
Award Title: Chicago Center for Physical Science-Oncology Innovation and Translation
PIs: Vadim Backman (NU), Lucy Godley (UChicago), Jack Kaplan (UIC)
New publications attributed to the award:
- Banigan EJ, van den Berg AA, Brandão HB, Marko JF, Mirny LA. Chromosome organization by one-sided and two-sided loop extrusion. Elife. 2020 Apr 6;9:e53558. (PubMed)
- Kloetgen A, Thandapani P, Ntziachristos P, Ghebrechristos Y, Nomikou S, Lazaris C, Chen X, Hu H, Bakogianni S, Wang J, Fu Y, Boccalatte F, Zhong H, Paietta E, Trimarchi T, Zhu Y, Van Vlierberghe P, Inghirami GG, Lionnet T, Aifantis I, Tsirigos A. Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia. Nat Genet. 2020 Apr;52(4):388-400. (PubMed)
- Tamashunas AC, Tocco VJ, Matthews J, Zhang Q, Atanasova KR, Paschall L, Pathak S, Ratnayake R, Stephens AD, Luesch H, Licht JD, Lele TP. High-throughput gene screen reveals modulators of nuclear shape. Mol Biol Cell. 2020 Jun 15;31(13):1392-1402. (PubMed)
- Wytock TP, Motter AE. Distinguishing cell phenotype using cell epigenotype. Sci Adv. 2020 Mar 18;6(12):eaax7798. eCollection 2020 Mar. (PubMed)
CBC Lever Award (L-004; 2012)
Award Title: Conte Center on the Computational Systems Genomics of Psychiatric Disorders
PIs: Andrey Rzhetsky (UChicago), Edwin Cook (UIC), Richard Morimoto (NU)
New publication attributed to the award:
- Mork RL, Hogan PG, Muenks CE, Boyle MG, Thompson RM, Sullivan ML, Morelli JJ, Seigel J, Orscheln RC, Bubeck Wardenburg J, Gehlert SJ, Burnham CD, Rzhetsky A, Fritz SA. Longitudinal, strain-specific Staphylococcus aureus introduction and transmission events in households of children with community-associated meticillin-resistant S aureus skin and soft tissue infection: a prospective cohort study. Lancet Infect Dis. 2020 Feb;20(2):188-198. (PubMed)
CBC Postdoctoral Research Award (PDR-065; 2015)
Award Title: Mass Spectrometric Quantification of Glycosphingolipids in Diabetic Skin
PIs: Duncan Hieu Dam (postdoc) and Amy Paller (PI; NU)
New publication attributed to the award:
- Dam DHM, Jelsma SA, Yu JM, Liu H, Kong B, Paller AS. Flotillin and AP2A1/2 Promote IGF-1 Receptor Association with Clathrin and Internalization in Primary Human Keratinocytes. J Invest Dermatol. 2020 Feb 3:S0022-202X(20)30128-7. Online ahead of print. (PubMed)
CBC Postdoctoral Research Award (PDR-089; 2016)
Award Title: Mapping the Transcriptional Landscape of Hypoxic Endothelial Cells
PIs: Jeffrey Klomp (postdoc) and Asrar Malik (PI; UIC)
New publication attributed to the award:
- Klomp J, Hyun J, Klomp JE, Pajcini K, Rehman J, Malik AB. Comprehensive transcriptomic profiling reveals SOX7 as an early regulator of angiogenesis in hypoxic human endothelial cells. J Biol Chem. 2020 Apr 10;295(15):4796-4808. (PubMed)
CBC Postdoctoral Research Award (PDR-103; 2016)
Award Title: Diffusion Tensor Imaging Analysis as a Tool to Evaluate Axonal Pathology in ALS
PIs: Rodolfo Gatto (postdoc) and Gerardo Morfini (PI; NU)
New publication attributed to the award:
- Gatto RG, Weissmann C, Amin M, Finkielsztein A, Sumagin R, Mareci TH, Uchitel OD, Magin RL. Assessing neuraxial microstructural changes in a transgenic mouse model of early stage Amyotrophic Lateral Sclerosis by ultra‐high field MRI and diffusion tensor metrics. Animal Model Exp Med. 2020;00:1–13. (onlinelibrary.wiley.com)
CBC Recruitment Resources Fund Award (R-001; 2006)
Award Title: CBC Senior Investigator
PI: Kevin White (Tempus, previously at UChicago)
New publications attributed to the award:
- Jiang Y, Giase G, Grennan K, Shieh AW, Xia Y, Han L, Wang Q, Wei Q, Chen R, Liu S, White KP, Chen C, Li B, Liu C. DRAMS: A tool to detect and re-align mixed-up samples for integrative studies of multi-omics data. PLoS Comput Biol. 2020 Apr 13;16(4):e1007522. eCollection 2020 Apr. (PubMed)
- Zraly CB, Zakkar A, Perez JH, Ng J, White KP, Slattery M, Dingwall AK. The Drosophila MLR COMPASS complex is essential for programming cis-regulatory information and maintaining epigenetic memory during development. Nucleic Acids Res. 2020 Apr 17;48(7):3476-3495. (PubMed)
CBC Recruitment Resources Fund Award (R-002; 2010)
Award Title: CBC Senior Investigator
PI: Neil Kelleher (NU)
New publications attributed to the award:
- Béguelin W, Teater M, Meydan C, Hoehn KB, Phillip JM, Soshnev AA, Venturutti L, Rivas MA, Calvo-Fernández MT, Gutierrez J, Camarillo JM, Takata K, Tarte K, Kelleher NL, Steidl C, Mason CE, Elemento O, Allis CD, Kleinstein SH, Melnick AM. Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response. Cancer Cell. 2020 May 11;37(5):655-673.e11. (PubMed)
- Ives A, Su T, Durbin KR, Early BP, Dos Santos Seckler H, Fellers RT, LeDuc RD, Schachner LF, Patrie SM, Kelleher NL. Using 10,000 fragment ions to inform scoring in native top-down proteomics. J Am Soc Mass Spectrom. 2020 May 21. Online ahead of print. (PubMed)
- Jiménez-Lamana J, Godin S, Aragonès G, Bladé C, Szpunar J, Łobinski R. Nickel Nanoparticles Induce the Synthesis of a Tumor-Related Polypeptide in Human Epidermal Keratinocytes. Nanomaterials (Basel). 2020 May 21;10(5):992. (PubMed)
- Kafader JO, Durbin KR, Melani RD, Des Soye BJ, Schachner LF, Senko MW, Compton PD, Kelleher NL. Individual Ion Mass Spectrometry Enhances the Sensitivity and Sequence Coverage of Top-Down Mass Spectrometry. J Proteome Res. 2020 Mar 6;19(3):1346-1350. (PubMed)
- Kafader JO, Melani RD, Durbin KR, Ikwuagwu B, Early BP, Fellers RT, Beu SC, Zabrouskov V, Makarov AA, Maze JT, Shinholt DL, Yip PF, Tullman-Ercek D, Senko MW, Compton PD, Kelleher NL. Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes. Nat Methods. 2020 Apr;17(4):391-394. (PubMed)
- Kosciuk T, Price IR, Zhang X, Zhu C, Johnson KN, Zhang S, Halaby SL, Komaniecki GP, Yang M, DeHart CJ, Thomas PM, Kelleher NL, Fromme JC, Lin H. NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle. Nat Commun. 2020 Feb 26;11(1):1067. (PubMed)
- McGee JP, Melani RD, Goodwin M, McAlister G, Huguet R, Senko MW, Compton PD, Kelleher NL. Voltage Rollercoaster Filtering of Low-Mass Contaminants During Native Protein Analysis. J Am Soc Mass Spectrom. 2020 Mar 4;31(3):763-767. (PubMed)
- Zhu W, Doubleday PF, Catlin DS, Weerawarna PM, Butrin A, Shen S, Wawrzak Z, Kelleher NL, Liu D, Silverman RB. A Remarkable Difference That One Fluorine Atom Confers on the Mechanisms of Inactivation of Human Ornithine Aminotransferase by Two Cyclohexene Analogues of γ-Aminobutyric Acid. J Am Chem Soc. 2020 Mar 11;142(10):4892-4903. (PubMed)
CBC Recruitment Resources Fund Award (R-004; 2010)
Award Title: CBC Junior Investigator
PI: Alex Ruthenburg (UChicago)
New publication attributed to the award:
- Sun X, Wang Z, Hall JM, Perez-Cervantes C, Ruthenburg AJ, Moskowitz IP, Gribskov M, Yang XH. Chromatin-enriched RNAs mark active and repressive cis-regulation: An analysis of nuclear RNA-seq. PLoS Comput Biol. 2020 Feb 10;16(2):e1007119. eCollection 2020 Feb. (PubMed)
CBC Recruitment Resources Fund Award (R-006; 2011)
Award Title: CBC Junior Investigator
PI: Michael Rust (UChicago)
New publication attributed to the award:
- Farhadi L, Ricketts SN, Rust MJ, Das M, Robertson-Anderson RM, Ross JL. Actin and microtubule crosslinkers tune mobility and control co-localization in a composite cytoskeletal network. Soft Matter. 2020 Mar 24. Online ahead of print. (PubMed)
CBC Recruitment Resources Fund Award (R-008; 2011)
Award Title: CBC Junior Investigator
PI: Daniel Dombeck (NU)
New publication attributed to the award:
- Zang N, Issa JB, Ditri TB, Bortone DS, Touve MA, Rush AM, Scanziani M, Dombeck DA, Gianneschi NC. Multicolor Polymeric Nanoparticle Neuronal Tracers. ACS Cent Sci. 2020 Mar 25;6(3):436-445. (PubMed)
CBC Scholar Award (SCH-036; 2014)
Award Title: CBC Scholar Award to Stefan Kathman (NU)
PI: Alexander Statsyuk (NU)
New publication attributed to the award:
- Olp MD, Sprague DJ, Goetz CJ, Kathman SG, Wynia-Smith SL, Shishodia S, Summers SB, Xu Z, Statsyuk AV, Smith BC. Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites. ACS Chem Biol. 2020 Apr 17;15(4):1036-1049. (PubMed)
CBC Scholar Award (SCH-039; 2014)
Award Title: CBC Scholar Award to Aleksandar Antanasijevic (UIC)
PI: Michael Caffrey (UIC)
New publication attributed to the award:
- Hussein AFA, Cheng H, Tundup S, Antanasijevic A, Varhegyi E, Perez J, AbdulRahman EM, Elenany MG, Helal S, Caffrey M, Peet N, Manicassamy B, Rong L. Identification of entry inhibitors with 4-aminopiperidine scaffold targeting group 1 influenza A virus. Antiviral Res. 2020 May;177:104782. (PubMed)
CBC Spark Award (S-005; 2009)
Award Title: Support for An Innovative CryoSTEM for Element Specific Imaging of Cells and Tissue
PIs: Thomas O’Halloran (NU), Jonathan Silverstein (UChicago) and Vinayak Dravid (NU)
New publications attributed to the award:
- Adams CJ, Krueger R, Meade TJ. A Multimodal Ca(II) Responsive Near IR-MR Contrast Agent Exhibiting High Cellular Uptake. ACS Chem Biol. 2020 Feb 21;15(2):334-341. (PubMed)
- Adams CJ, Meade TJ. Gd(III)–Pt(IV) theranostic contrast agents for tandem MR imaging and chemotherapy. Chem. Sci., 2020, 11, 2524. (pubs.rsc.org)
- Batlle D, Wysocki J, Satchell K. Soluble Angiotensin-Converting Enzyme 2: A Potential Approach for Coronavirus Infection Therapy? Clin Sci (Lond). 2020 Mar 13;134(5):543-545. (PubMed)
- Bobbala S, Allen SD, Yi S, Vincent M, Frey M, Karabin NB, Scott EA. Employing bicontinuous-to-micellar transitions in nanostructure morphology for on-demand photo-oxidation responsive cytosolic delivery and off-on cytotoxicity. Nanoscale. 2020 Mar 5;12(9):5332-5340. (PubMed)
- Vincent MP, Bobbala S, Karabin NB, Frey M, Liu Y, Navidzadeh JO, Stack T, Scott EA. Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets. bioRxiv preprint, this version posted April 25, 2020. (PubMed)
CBC Spark Award (S-007; 2011)
Award Title: Leptin Peptide in Diabetes: From Mechanism to Therapeutics
PIs: Nissim Hay (UIC), Joseph Bass (NU), Graeme Bell (UChicago), Louis Philipson (UChicago)
New publication attributed to the award:
- Levine DC, Hong H, Weidemann BJ, Ramsey KM, Affinati AH, Schmidt MS, Cedernaes J, Omura C, Braun R, Lee C, Brenner C, Peek CB, Bass J. NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. Mol Cell. 2020 Jun 4;78(5):835-849.e7. (PubMed)