cbc scholars bios
Jonathan Woon Teck Yap
CBC Scholar: Class of 2012
PhD Candidate, Department of Biomedical Engineering, NU
Advisor: Lonnie Shea
Email:
SHEA LAB WEBPAGE
RESEARCH INTERESTS:
My research interests lie in the field of islet transplantation and tolerance induction for the treatment of type 1 diabetes. Current pancreatic islet transplantation is hindered by an active autoimmune response against the transplanted islets that requires generalized immunosuppression that renders the patient highly susceptible to infections and the development of neoplasia. In addition, allogeneic transplants are subjected to active graft rejection. My work focuses on the development of antigen and gene delivery vehicles for the induction of antigen-specific tolerance to treat autoimmune diseases and to prevent allogeneic transplant rejection. Recently, I have successfully prevented and treated disease in the remitting-relapsing experimental autoimmune encephalomyelitis (R-EAE) model of the human autoimmune disease, multiple sclerosis.
PUBLICATIONS:
Jain S, Yap WT, Irvine DJ. Synthesis of protein-loaded hydrogel particles in an aqueous two-phase system for coincident antigen and CpG oligonucleotide delivery to antigen-presenting cells. Biomacromolecules. 2005 Sep-Oct;6(5):2590-600. (PubMed)
Fong SWA, Yap WT, Vittal JJ, Henderson W, Hor TSA. Mass spectrometry-directed synthesis of ‘early–late’ sulfide-bridged heterobimetallic complexes from the metalloligand [Pt2(PPh3)4(μ-S)2] and oxo compounds of vanadium(V), molybdenum(VI) and uranium(VI). J. Chem. Soc., Dalton Trans. 2002, 1826-1831. (RCS Publishing)
Fong SWA, Yap WT, Vittal JJ, Hor TSA, Henderson W, Oliver AG, Rickard CEF. A combinatorial-like probe on the reactivity of the {Pt2S2} core of Pt2(PPh3)4(μ-S)2 by electrospray mass spectrometry. Synthesis and structures of novel heterometallic sulfide aggregates of gold(III), mercury(II), and tin(IV) with platinum(II). J. Chem. Soc., Dalton Trans. 2001, 1986-2002. (RCS Publishing)
AWARDS, ACTIVITIES AND SERVICE:
- 2012 CBC Scholar
- 2007 Ryan Fellowship Chicago
- Volunteer judge at 2011 John T. McCutcheon Elementary School
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