cbc scholars bios
Rima Chaudhuri, PhD
CBC Scholar: Class of 2010
Department of Bioengineering and Center for Pharmaceutical Biotechnology, UIC, Advisor: Michael Johnson
JOHNSON LAB WEBPAGE
Current position: Postdoctoral Researcher, PI: Modesto Orozco, Ph.D., Institute of Research for Biomedicine, University of Barcelona at the Barcelona Science Park, Spain
Email:
OROZCO LAB WEBPAGE
EDUCATION:
University of Illinois at Chicago
PhD, Bioinformatics
2005 - 2010
Georgia College & State University
BA, Magna cum Laude, Major in Management of Information Systems (MIS), minor in Computer Science,
2000 - 2004
RESEARCH INTERESTS:
Rima successfully defended her thesis work in December 2010. Her dissertation was titled: Drug Discovery and Design for the inhibition SARS-Coronavirus and Hepatitis C virus.
Rima is currently a postdoctoral researcher at the Institute of Research for Biomedicine (IRB, Barcelona) of University of Barcelona at the Barcelona Science Park. She joined the Molecular Modelling and Bioinformatics laboratory of Modesto Orozco, Ph.D. She started at this position in March of 2011 and has been actively working on a physics based method to enhance docking enrichment for virtual highthroughput screening of chemical databases against therapeutic targets for the discovery and eventual design of lead drug molecules. In her current project, she is working on multitarget screening and re-positioning of known drugs. This involves network medicine approaches to human disease, conceptualization and application of druggability tests ensued by inhibitor design for receptors sharing common binding site features.
PUBLICATIONS:
Lee H, Torres J, Truong L, Chaudhuri R, Mittal A, Johnson ME. Reducing agents affect inhibitory activities of compounds: Results from multiple drug targets. Anal Biochem. 2012 Jan 18;423(1):46-53. (PubMed)
Chaudhuri R, Tang S, Zhao G, Lu H, Case DA, Johnson ME. Comparison of SARS and NL63 Papain-Like Protease Binding Sites and Binding Site Dynamics: Inhibitor Design Implications. J Mol Biol. 2011 Nov 25;414(2):272-88. (PubMed)
Ghosh AK, Takayama J, Rao KV, Ratia K, Chaudhuri R, Mulhearn DC, Lee H, Nichols DB, Baliji S, Baker SC, Johnson ME, Mesecar AD. Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation. J Med Chem. 2010 Jul 8;53(13):4968-79. (PubMed)
Ghosh AK, Takayama J, Aubin Y, Ratia K, Chaudhuri R, Baez Y, Sleeman K, Coughlin M, Nichols DB, Mulhearn DC, Prabhakar BS, Baker SC, Johnson ME, Mesecar AD. Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease. J Med Chem. 2009 Aug 27;52(16):5228-40. (PubMed)
Ratia K, Pegan S, Takayama J, Sleeman K, Coughlin M, Baliji S, Chaudhuri R, Fu W, Prabhakar BS, Johnson ME, Baker SC, Ghosh AK, Mesecar AD. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24. (PubMed)
AWARDS, HONORS AND OFFICES HELD:
- CBC Scholar, 2010
- Travel award to the Keystone Symposium, Whistler, Canada, 2010
- Honorable mention, University of Illinois Graduate Research Forum, 2009
- 1st place, University of Illinois Graduate Research Forum, 2007
- Scientific Research Society: Sigma Xi
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