cbc scholars bios
Lou Dore
CBC Scholar: Class of 2011
PhD Candidate, Department of Medicine, NU; Advisor: John Crispino
Email:
CRISPINO LAB WEBPAGE
RESEARCH INTERESTS:
My research is focused on the molecular mechanisms of transcription regulation during the process of mammalian blood cell development. Specifically, I am interested in the process by which GATA and ETS factors choose their binding sites during erythroid and megakaryocytic differentiation. In addition, I am using ChIP-Sequencing and gene expression profiling to identify novel pathways regulated by master transcription factors during the development of these blood lineages. Finally, I am interested in how GATA family transcription factors control chromatin structure to regulate cell lineage decision and identity.
PUBLICATIONS:
Doré LC, Chlon TM, Brown CD, White KP, Crispino JD. Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis. Blood. 2012 Mar 1. [Epub ahead of print] (Blood)
Doré LC, Crispino JD. Transcription factor networks in erythroid cell and megakaryocyte development.Blood. 2011 Jul 14;118(2):231-9. Review. (PubMed)
Huang Z, Dore LC, Li Z, Orkin SH, Feng G, Lin S, Crispino JD. GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Mol Cell Biol. 2009 Sep;29(18):5168-80. (PubMed)
AWARDS:
CBC Scholar 2011
Katten Muchin Rosenman Travel Award from the Cancer Center at Northwestern and a Travel Award from the American Society of Hematology, both to attend the Annual Meeting of the American Society of Hematology in Orlando, Florida in December 2010
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