Updated: December 2, 2013
CBC Scholar: Class of 2011
PhD Candidate, Department of Medicine, NU; Advisor: John Crispino
CRISPINO LAB WEBPAGE
Lou successfully defended his PhD Thesisin June 2012 and currently is a post-doc with Chuan He at UChicago.
My research is focused on the molecular mechanisms of transcription regulation during the process of mammalian blood cell development. Specifically, I am interested in the process by which GATA and ETS factors choose their binding sites during erythroid and megakaryocytic differentiation. In addition, I am using ChIP-Sequencing and gene expression profiling to identify novel pathways regulated by master transcription factors during the development of these blood lineages. Finally, I am interested in how GATA family transcription factors control chromatin structure to regulate cell lineage decision and identity.
Malinge S, Chlon T, Doré LC, Ketterling RP, Tallman MS, Paietta E, Gamis AS, Taub JW, Chou ST, Weiss MJ, Crispino JD, Figueroa ME. Development of acute megakaryoblastic leukemia in Down syndrome is associated with sequential epigenetic changes. Blood. 2013 Oct 3;122(14):e33-43. (PubMed)
Malinge S, Thiollier C, Chlon TM, Doré LC, Diebold L, Bluteau O, Mabialah V, Vainchenker W, Dessen P, Winandy S, Mercher T, Crispino JD. Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling. Blood. 2013 Mar 28;121(13):2440-51. (PubMed)
Chlon TM, Doré LC, Crispino JD. Cofactor-Mediated Restriction of GATA-1 Chromatin Occupancy Coordinates Lineage-Specific Gene Expression. Mol Cell. 2012 Aug 24;47(4):608-21. (PubMed)
Doré LC, Chlon TM, Brown CD, White KP, Crispino JD. Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis. Blood. 2012 Mar 1. [Epub ahead of print] (Blood)
Doré LC, Crispino JD. Transcription factor networks in erythroid cell and megakaryocyte development.Blood. 2011 Jul 14;118(2):231-9. Review. (PubMed)
Huang Z, Dore LC, Li Z, Orkin SH, Feng G, Lin S, Crispino JD. GATA-2 reinforces megakaryocyte development in the absence of GATA-1. Mol Cell Biol. 2009 Sep;29(18):5168-80. (PubMed)
CBC Scholar 2011-2012
Katten Muchin Rosenman Travel Award from the Cancer Center at Northwestern and a Travel Award from the American Society of Hematology, both to attend the Annual Meeting of the American Society of Hematology in Orlando, Florida in December 2010