Gene Regulatory Networks Directing Hematopoietic Cellular Fates

Type of Award: Catalyst
Date Awarded: January 2008
Award End Date: December 2008
Amount Awarded: $ 199,538.00
PI(s): Harinder Singh, PhD, UChicago; John Crispino, PhD, NU; Aaron Dinner, PhD, UChicago;

Abstract: Different mammalian cell types turn on subsets of genes that enable the cells to perform distinct functions within tissues and organ systems. The genetic circuits and switches that control gene activity and the generation of different cell types are poorly understood. We propose to discover and comprehensively analyze these circuits using a variety of experimental and theoretical approaches within the context of the blood and immune system. Detailed knowledge of these genetic circuits should enable their manipulation to efficiently generate specific blood and immune cells starting from stem cells. Such knowledge will also provide a new and very powerful means of assessing diseased states of the blood system such as leukemias and aid in their diagnosis and therapy.