Novel PHLPP Peptide for Asystole/PEA Resuscitation

Type of Award: accelerator
Award Number: A-008
Award Period: December 2018 - November 2019
Amount Awarded: $ 99,926.00
PI(s): Terry Vanden Hoek, UIC;

Abstract: Cardiac arrest affects 600,000 people annually in the United States and is a leading cause of death. No drugs exist that improve survival from this lethal disease. While cooling a few degrees improves survival, it is difficult to implement clinically during cardiopulmonary resuscitation (CPR) and when started after CPR protects against ventricular fibrillation (VF) cardiac arrest (with expected 50% survival), but not against the most lethal forms of cardiac arrest, pulseless electrical activity (PEA) and asystole (with about 10% survival). We developed a novel peptide that reproduces critical mechanisms of CPR cooling protection without physically cooling. It significantly increases survival in pigs with VF cardiac arrest. We propose to further examine the benefit of this peptide using mouse asystole and pig PEA models. We hypothesize that this peptide administered intravenously during CPR improves neurologically intact survival and will extend protective effects of cooling to the majority of cardiac arrest patients.