Carbapenem-Resistant K. Pneumoniae Genomic Biomarkers that Predict Poor Outcomes

Type of Award: catalyst
Award Number:
Award Period: September 2018 - August 2020
Amount Awarded: $ 249,983.00
PI(s): Alan Hauser, NU; Zackery Bulman, UIC;

Abstract: Infections caused by carbapenem-resistant Enterobacteriaceae (CRE) are categorized in the highest threat level by the CDC, WHO, and IDSA. The most prevalent CRE species is Klebsiella pneumoniae (Kp), in which carbapenem resistance is consistently coupled with other drug resistance mechanisms leaving clinicians with an extremely limited therapeutic armamentarium. In the past, carbapenem-resistant Kp (CR-Kp) strains had relatively low levels of virulence, but recent evidence suggests this is changing. As a result, clinicians are increasingly encountering highly invasive CR-Kp infections that evade antibiotic therapy. Unfortunately, many aspects of CR-Kp antimicrobial resistance and pathogenicity remain poorly understood. We propose herein to investigate unique bacterial genetic markers that enhance antibiotic resistance and virulence in CR-Kp strains.